April 17, 2026 · Boone · Hamilton
Indiana Moves Toward Nuclear Base Load as Life Sciences Expansion Tightens Central Indiana's Labor Market
Indiana is exploring small modular reactors for industrial base load while a $200M life sciences expansion in Fishers tightens central Indiana's labor market through
Governor Braun's letter of intent with Eli Lilly to explore small modular reactors at the LEAP District in Boone County is the most consequential long-term energy story in Indiana nuclear energy manufacturing right now, and a $200 million life sciences expansion in Fishers is about to absorb nearly 1,000 skilled workers from the same labor pool your operation depends on. Three stories this week. All of them run back to the same two constraints: power supply and skilled workers.
01Boone
Indiana Explores Small Modular Reactors for Industrial Base Load at the LEAP District
Governor Braun signed a non-binding letter of intent with Eli Lilly and Indiana's Office of Energy Development to evaluate deploying small modular nuclear reactors and other advanced nuclear technologies at the LEAP Research and Innovation District in Lebanon, Boone County, where Eli Lilly has announced more than $13 billion in investment across multiple drug manufacturing facilities. This is not a medical isotope play.
02Statewide
Incog BioPharma's $200M Fishers Expansion Will Pull Nearly 1,000 Workers from Central Indiana's Labor Market by 2030
Incog BioPharma, a sterile injectables contract development and manufacturing organization, is investing approximately $200 million to expand its Fishers campus to roughly 300,000 square feet on a 21-acre site. Construction begins in early 2026.
03Statewide
Former Governor Holcomb: Power Supply and Skilled Workers Still Determine Who Wins
Former Governor Eric Holcomb published a piece in Time magazine in January 2026 arguing that AI will drive an American manufacturing renaissance. The two variables he says determine whether Indiana captures or misses that opportunity: the supply of skilled workers and electrical power, in that order.
Questions for Your Morning Huddle
Q: What is Indiana's small modular reactor letter of intent with Eli Lilly actually committing to? A: It's a non-binding agreement to evaluate the feasibility of deploying SMRs and other advanced nuclear technologies at the LEAP District in Lebanon, not a construction commitment. Indiana's Office of Energy Development is now assigned to coordinate grid siting and permitting work, and those assessments are the documents that will tell you whether this is moving and at what cost.
Q: How does Incog BioPharma's Fishers expansion affect Hamilton County manufacturers competing for skilled workers? A: Incog is building toward nearly 1,000 employees in operations, engineering, quality, and administration by 2030. If your facility depends on any of those skill sets in the Hamilton County labor market, you are competing directly, and your retention and compensation strategy should already account for that pressure through the end of the decade.
Q: What are the two variables former Governor Holcomb says will determine whether Indiana captures AI-driven manufacturing growth? A: Skilled workers and electrical power, in that order. Holcomb's argument is that future factories will be more specialized, not necessarily smaller in total employment, and the operators who build the workforce and power infrastructure to support that shift are the ones who will still be growing in 2033.
All three stories this week point to the same exposure: operators who are not actively managing their long-term energy procurement strategy and workforce pipeline are building risk into both their cost structure and their production capability for the rest of this decade.
This brief
More from Boone County
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- NIPSCO IURC Investigation Goes Official, Indiana Industrial Property Assessments Jump 25.8%, and Honda's Ohio Plant Opens a Supplier Window
Manufacturers Energy Grant Program
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